The following manuscripts have been published or are currently in press. Listings are in chronological order, unless otherwise noted.
| Title | Publication | Date/Location |
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| Assessing Nonresponse Bias at Follow-Up in a Large Prospective Cohort of Relatively Young and Mobile Military Service Members | BMC Medical Research Methodology | 2010 Oct;10(1):99 |
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Littman AJ, Boyko EJ, Jacobson IG, Horton JL, Gackstetter GD, Smith B, Hooper TI, Amoroso PJ, Smith TC, for the Millennium Cohort Study Team In this study population, nonresponse to the follow-up questionnaire did not result in appreciable bias as reflected by comparing measures of association for selected outcomes using complete case and inverse probability weighted methods. |
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| Exploratory Factor Analysis of Self-Reported Symptoms in a Large, Population-Based Military Cohort | BMC Medical Research Methodology | 2010 Oct;10(1):94 |
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Kelton ML, LeardMann CA, Smith B, Boyko EJ, Hooper TI, Gackstetter GD, Bliese PD, Hoge CW, Smith TC, for the Millennium Cohort Study Team Using exploratory factor analysis, this study examined mental and physical health symptom covariance structure. A 14-factor model accounted for 60% of the variance indicating a reasonable amount of construct overlap and that the number and type of questions appropriately assess a spectrum of heterogeneous symptoms. |
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| Application of Latent Semantic Analysis for Open-Ended Responses in a Large, Epidemiologic Study | BMC Medical Research Methodology | 2011 Oct;11:136 |
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Leleu TD, Jacobson IG, LeardMann CA, Smith B, Foltz PW, Amoroso PJ, Derr M, Ryan MAK, Smith TC, for the Millennium Cohort Study Team Using latent semantic analysis to analyze the final open-ended text field on the Millennium Cohort questionnaire helped identify important topic areas for future survey questions and also revealed the most common areas of concern for participants were illness and injuries, exposures, and exercise. Subjects with worse self-reported general health were more likely to provide a response in the open-ended text field than subjects with better general health. |
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| Multiple imputation validation study: Addressing unmeasured survey data in a longitudinal design | BMC Medical Research Methodology | 2021 Jan 6;21(1):5 |
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Kolaja CA, Porter B, Powell TM, Rull RP, Millennium Cohort Study Team This study examined the efficiency and feasibility of multiple imputation (MI) to recover data from a question completely missing at a follow-up survey assessment. Specifically, the suicidal ideation item on the depression module of the Patient Health Questionnaire was set to missing on a follow-up survey and then filled in using different MI models. Imputed and self-reported suicidal ideation were similarly associated with the related constructs of sleep duration and smoking status, suggesting that MI allowed for the inclusion of an otherwise missing item as a covariate in statistical models. |
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| Survey response over 15 years of follow-up in the Millennium Cohort Study | BMC Medical Research Methodology | 2023 Sep 9 | doi: 10.1186/s12874-023-02018-z |
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Kolaja CA, Belding JN, Boparai SK, Castañeda SF, Geronimo-Hara TR, Powell TM, Tu XM, Walstrom JL, Sheppard BD, Rull RP; Millennium Cohort Study Team Across a 3-15 year follow-up period, the average response rate among almost 198,833 Millennium Cohort Study participants was 60%. Factors associated with follow-up survey response over time included increased educational attainment, married status, female sex, older age, military deployment, greater life stress, and poorer mental/physical health status. |
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| Associations of Military Divorce with Mental, Behavioral, and Physical Health Outcomes | BMC Psychiatry | 2015; 15:128 |
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Wang L, Seelig AD, MacDermid Wadsworth S, McMaster HS, Alcarez J, Crum-Cianflone NF This prospective study investigated the associations of recent divorce with health outcomes among US Service members. Findings indicate that recent divorce is associated with adverse mental health outcomes, including new-onset PTSD and depression, and risky behaviors, such as smoking initiation and new-onset alcohol-related problems, after adjusting for relevant demographics and covariates. Given these findings, it is important to make sure resources are available to support recently divorced Service members, since divorce may not only affect personal quality of life, but also military force readiness. |
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| Factors Associated With Persistent Posttraumatic Stress Disorder Among U.S. Military Service Members and Veterans | BMC Psychiatry | 2018 Feb 17;18(1):48 |
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Armenta RF, Rush T, LeardMann CA, Millegan J, Cooper AD, Hoge, CW Among service members and veterans who screened positive for PTSD at baseline, 47% met the criteria for persistent PTSD. Combat experiences and PTSD severity were found to be the most salient factors associated with persistent PTSD; other associated factors included co-morbid conditions, sleep problems, and somatic symptoms. These findings corroborate the need for more comprehensive and accessible treatment to address both PTSD symptoms and comorbid conditions. |
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| Longitudinal Trajectories of Comorbid PTSD and Depression Symptoms Among U.S. Service Members and Veterans | BMC Psychiatry | 2019 Dec 13;19(1):396 |
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Armenta RF, Walter KH, Geronimo-Hara TR, Porter B, Stander V, LeardMann CA, for the Millennium Cohort Study Team This study examined the patterns of PTSD and depression symptoms over time among those with probable comorbid PTSD and depression at baseline. We found that PTSD and depression symptoms tended to move in tandem. Although many service members and veterans experienced a reduction of symptoms over time, one quarter of individuals reported high levels of PTSD and depression symptoms during the almost 12 years of follow-up. Notable factors associated with elevated comorbid PTSD/depression symptoms included older age, combat experiences, and having other co-occurring health problems. Results highlight the need for comprehensive assessment and treatment of comorbid PTSD/depression. |
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| Posttraumatic Stress Disorder and Risk of Selected Autoimmune Diseases among US Military Personnel | BMC Psychiatry | 2020 Jan 15; 20 (1):23 |
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Bookwalter DB, Roenfeldt KA, LeardMann CA, Kong SY, Riddle MS,Rull RP This study investigated the association between PTSD and risk of developing selected autoimmune diseases among US active duty service members. Among 120,572 participants followed for an average of 5 years, risk of any of the selected new-onset autoimmune diseases was 58% higher for those with a history of PTSD compared to those with no history. Observed associations did not differ by specific types of trauma experienced. Future research is needed to understand the physiological pathways that may link PTSD with increased risk of immune-mediated inflammatory diseases. |
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| The Physical and Mental Health of a Large Military Cohort: Baseline Functional Health Status of the Millennium Cohort | BMC Public Health | 2007 Nov;7(147):340 |
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Smith TC, Zamorski M, Smith B, Riddle JR, LeardMann CA, Wells TS, Engel CC, Hoge CW, Adkins J, Blazer D, for the Millennium Cohort Study Team The functional health of service members in this 22-year longitudinal study compares favorably at baseline with other civilian and military populations. |
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