Publications

The following manuscripts have been published or are currently in press. Listings are in chronological order, unless otherwise noted.

Research Publication 2
Title Publication Date/Location
Posttraumatic Stress Disorder and Risk of Selected Autoimmune Diseases among US Military Personnel BMC Psychiatry 2020 Jan 15; 20 (1):23

Bookwalter DB, Roenfeldt KA, LeardMann CA, Kong SY, Riddle MS,Rull RP

This study investigated the association between PTSD and risk of developing selected autoimmune diseases among US active duty service members. Among 120,572 participants followed for an average of 5 years, risk of any of the selected new-onset autoimmune diseases was 58% higher for those with a history of PTSD compared to those with no history. Observed associations did not differ by specific types of trauma experienced. Future research is needed to understand the physiological pathways that may link PTSD with increased risk of immune-mediated inflammatory diseases.

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Posttraumatic Stress Disorder Symptom Association With Subsequent Risky and Problem Drinking Initiation Journal of Addiction Medicine 2018 Sep/Oct;12(5):353-362

Bensley KM, Seelig AD, Armenta RF, Rivera AC, Peterson AV, Jacobson IG, Littman AJ, Maynard C, Bricker JB, Boyko EJ, Rull RP, and Williams EC

This study investigated the association between PTSD symptoms and symptom clusters and the initiation of risky and problem drinking. One PTSD symptom (irritability/anger) was associated with a higher risk of risky drinking initiation. Five PTSD symptoms (restricted affect, sense of foreshortened future, exaggerated startle response, sleep disturbance, and irritability/anger) and two symptom clusters (dysphoric arousal and emotional numbing) were associated with an increased risk of problem drinking initiation.

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Predeployment Sleep Duration and Insomnia Symptoms as Risk Factors for New-Onset Mental Health Disorders Following Military Deployment Sleep 2013 Jul 1;36(7):1009-1018

Gehrman P, Seelig AD, Jacobson IG, Boyko EJ, Hooper TI, Gackstetter GD, Ulmer CS, Smith TC

This study showed that combat-related trauma and predeployment insomnia symptoms were significantly associated with developing posttraumatic stress disorder, depression, and anxiety following deployment. Assessment of insomnia symptoms predeployment may help to better identify those at highest risk for subsequent adverse mental health outcomes.

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Preinjury Psychiatric Status, Injury Severity, and Postdeployment Posttraumatic Stress Disorder Archives of General Psychiatry 2011 May;68(5):496-504

Sandweiss DA, Slymen DJ, LeardMann CA, Smith B, White MR, Boyko EJ, Hooper TI, Gackstetter GD, Amoroso PJ, Smith TC, for the Millennium Cohort Study Team

Physical injuries were significantly associated with postdeployment PTSD. Baseline psychiatric status was also significantly associated with postdeployment PTSD, irrespective of injury severity. Deployed service members who suffer from a predeployment psychiatric condition or injury while deployed may benefit from interventions targeted to prevent postdeployment PTSD or ensure early identification and treatment.

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Prescription Stimulants and Post-Traumatic Stress Disorder Among US Military Service Members Journal of Traumatic Stress 2015 Dec;28(6):585-589

Crum-Cianflone NF, Frasco M, Armenta RF, Phillips CJ, Horton J, Ryan MAK, Russell DW, LeardMann CA

Millennium Cohort data from U.S. military members who completed the baseline survey, and two follow-up surveys were evaluated to determine associations between receipt of prescription stimulants and PTSD. Prescription stimulants were significantly associated with incident PTSD after adjustment for attention-deficit/hyperactivity disorder, baseline mental and physical health status, deployment experiences, and other known confounders. Findings from this study may inform the underlying pathogenesis of and preventive strategies for PTSD.

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Prevalence of Chronic Multisymptom Illness/Gulf War Illness Over Time Among Millennium Cohort Participants, 2001 to 2016 Journal of Occupational and Environmental Medicine 2020 Jan;62(1):4-10

Porter B, Long K, Rull RP, Dursa EK for the Millennium Cohort Study Team

Chronic multisymptom illness/Gulf War illness (CMI/GWI) is a signature illness of the 1990-1991 Gulf War. Using a modified CMI/GWI definition, this study estimated the prevalence of CMI/GWI from 2001-2016 among Gulf War veterans and two other non-deployed groups enrolled in the Millennium Cohort Study. Overall, Gulf War veterans had the highest prevalence of CMI/GWI across the study period. The prevalence among all three groups increased substantially at approximately the same rate from 2001 to 2016.

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Prior Assault and Posttraumatic Stress Disorder After Combat Deployment Epidemiology 2008 May;19(3):505-12

Smith TC, Wingard DL, Ryan MAK, Kritz-Silverstein D, Slymen DJ, Sallis JF, for the Millennium Cohort Study Team

In contrast to hypotheses that survival from trauma represents or confers resilience, these findings suggest vulnerability to combat stress and PTSD among survivors of prior assault.

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Prior Health Care Utilization as a Determinant to Enrollment in a 21-Year Prospective Study, the Millennium Cohort Study European Journal of Epidemiology 2008 Feb;23(2):79-87

Wells TS, Jacobson IG, Smith TC, Spooner CN, Smith B, Reed RJ, Amoroso PJ, Ryan MAK, for the Millennium Cohort Study Team

Few health differences between Millennium Cohort responders and non-responders were found when comparing healthcare utilization in the 12 months preceding study invitation.

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Profile of Two Cohorts: UK and US Prospective Studies of Military Health International Journal of Epidemiology 2012 Oct;41(5):1272-82

Pinder RJ, Greenberg N, Boyko EJ, Gackstetter GD, Hooper TI, Murphy D, Ryan MA, Smith B, Smith TC, Wells TS, Wessely S, for the Millennium Cohort Study Team

Despite differences and limitations in methodologies, analyses of these two cohorts provide the prospect of driving improvement and innovation in military health and extending findings to other occupational populations.

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Prospective Assessment of Chronic Multisymptom Illness Reporting Possibly Associated with Open-Air Burn Pit Smoke Exposure in Iraq Journal of Occupational and Environmental Medicine 2012 June;54(6):682-688

Powell TM, Smith TC, Jacobson IG, Boyko EJ, Hooper TI, Gackstetter GD, Phillips CJ, Smith B, for the Millennium Cohort Study Team

There was no increase in chronic multisymptom illness (CMI) symptom reporting in Army and Air Force personnel deployed within a 2-, 3-, or5-mile radius of documented open-air burn pits located in Iraq at Joint Base Balad, Camp Taji, and Camp Speicher compared with other deployed personnel. This initial report on possible burn pit exposure associated with CMI at apopulation-level is reassuring, but future research evaluating the potential association of burn pit smoke and CMI should utilize individual exposure data when possible.

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